Historical studies of the development of C. The small nematode roundworm Caenorhabditis elegans has become one of the main model organisms, allowing for major discoveries in molecular and cell biology, on par with the vinegar fly ( Drosophila melanogaster) and baker's yeast ( Saccharomyces cerevisiae). elegans Bergerac to higher temperatures, the significance of which remains to be clarified.
Jean Brun, a student of Nigon, performed a long and remarkable experiment in acclimatization of C. elegans, concerning the difference in heat resistance of the Bergerac and Bristol strains. With Helene Fatt, Dougherty also performed the first genetic study of natural variation in C. Dougherty and his team devoted most of their work to finding a defined culture medium to screen for physiological mutants, focusing on C. With Ellsworth Dougherty, Nigon isolated and studied a C. elegans hermaphrodites and males, described the meiotic behavior of chromosomes in XX hermaphrodites and X0 males and, using tetraploids, correctly inferred that sex was determined by X chromosome to autosome dosage. elegans was again isolated and chosen as a main subject by Victor Nigon in the 1940-50s. Hikokura Honda determined its hermaphrodite chromosomal content in 1925. Maupas in his 1900 opus on reproduction had already chosen C. A common thread in this period, aided by the variety in modes of reproduction of different nematode species, is found in studies of meiosis, fertilization, heredity, and sex determination. We focus on the period that started in 1899 with the first publication of Emile Maupas mentioning Rhabditis elegans and ended in 1974 with the first publications by Brenner. Here we review the pre-Brenner history of the use of free-living nematodes as models for general questions in biology.
The choice of Sydney Brenner to adopt this species in the mid-1960s and the success of his team in raising it to a model organism status have been told ( Brenner, 2001 Ankeny, 2001). Mark the Retain History checkbox if you want to prevent engagement event history from being deleted, then select Next.The nematode Caenorhabditis elegans is now a major model organism in biology.You have the option to delete workpapers, then select Next.You have the option to continue with unsigned workpapers or apply sign offs, then select Next.Select Next in the Finalize Engagement panel to continue the process.Select the X link in the browser tab to close the report.The Finalize Diagnostic report displays None in the sections for which the category does not apply.
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